Browse wiki

User:Eneumann/Kinases

Canc Mol Genetics	Dom +
Canc Syndrome	Familial malignant melanoma +
Cancer Mut	Somatic + , Germline +
Chr	7 + , 12 +
Chr Band	7q21-q22 + , 12q14 +
Disease+Type	Cancer + , Inflammation + , Viral infection + , Cardiovascular + , Neurodegeneration + , Diabetes + , CNS + , Cognition +
GeneID	1021 + , 1019 +
Group	CMGC +
Label	p38 (alpha,beta,gamma,delta)  + , CDK6  + , CDK9  + , CDK2  + , GSK3alpha and GSK3beta  + , HIPK1  + , HIPK2  + , CDC2 (CDK1)  + , Erk5 (BMK1)  + , JNK3  + , JNK1  + , Dyrk1A  + , CDK4  +
Modification date
Molecular+Basis	Overexpression + , Translocation + , Expression + , SNP + , Activated + , Loss-of-heterozygosity + , Splice-Change + , Gain-of-function Mutation + , Amplified + , Methylation +
Mut Type	T + , Mis +
Name	p38 (alpha,beta,gamma,delta)  + , CDK6  + , cyclin-dependent kinase 6  + , CDK9  + , CDK2  + , GSK3alpha and GSK3beta  + , HIPK1  + , HIPK2  + , CDC2 (CDK1)  + , Erk5 (BMK1)  + , JNK3  + , JNK1  + , Dyrk1A  + , CDK4  + , cyclin-dependent kinase 4  +
Notes	Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas (Medline:9102208) and rodent cancers (Medline:12538879, 11719459). OMIM Gene Id: 603368. + , Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor (Medline:12702766). OMIM Gene Id: 608003. + , Possible tumor suppressor. Activates p53 in response to UV light, causing growth arrest and apoptosis. Required for cisplatin-induced apoptosis (Medline:14729469). Downregulated in breast and thyroid carcinomas. OMIM Gene Id: 606868. + , Candidate gene for some aspects of Down's Syndrome: located in DS critical region, and overexpression in mice gives rise to similar neurological abnormalities (Medline: 15198122). OMIM Gene Id: 600855. +
OMIM	602399 + , 603368 + , 603251 + , 116953 + , 605004 + , 608003 + , 606868 + , 116940 + , 602521 + , 602897 + , 601158 + , 600855 + , 123829 +
Origin	Http://eneumann.org/exhibit/kinase demo/kinases vu.html +
Symbol	CDK6 + , CDK4 +
Tissue	L + , E +
Transloc Partner	MLLT10 +
Tum Germ Mut	Melanoma +
Tum Soma Mut	ALL +
Type	Kinase  + , Mutant_Gene  +
Uri	Http://eneumann.org/exhibit/kinase demo/item +
Has improper value forThis property is a special property in this wiki.	Notes  +

hide properties that link here

	No properties link to this page.

 

Enter the name of the page to start browsing from.